Did you hear about the new nasal birth control spray? It works great but they can't find anyone who has nasal sex.
gavinray 2 hours ago [-]
"Reverse brain aging", sure, in the same sense that taking Vitamin C reverses aging.
The nasal spray reduced markers of inflammation in hippocampal microglial cells.
A lot of things reduce inflammation. That is not "reversing ageing".
Of course, "reduces inflammation" doesn't headline very well...
fragmede 1 hours ago [-]
Tell that to Bryan Johnson.
mawadev 2 hours ago [-]
The article is also heavily ai generated, I call bs on every single bit
bigmattystyles 2 hours ago [-]
I thought the url said temu at first.
dwa3592 1 hours ago [-]
>>The article is also heavily ai generated
can you please share your methodology for detecting ai please?
TonyAlicea10 1 hours ago [-]
“The most surprising part? It all happened within weeks and lasted for months.”
That’s an AI tell. It may not be entirely LLM-generated, the various direct quotations help a lot, but there are touches that definitely feel like an LLM had a hand here.
ShinyLeftPad 16 minutes ago [-]
That's not an "AI tell". If you read anything in recent decades, this is a turn of speech human writers wrote for ages and still write.
andregr 9 minutes ago [-]
"It's not just x, it's y." Absolutely clear tell, especially at this frequency. Examples from the article below:
"Over decades, it doesn’t just wear down, it also starts to run hot."
"... the therapy didn’t just clear brain fog, it physically improved the brain’s ability to process and store information."
The quotes as well:
"'... Not just living longer, but living smarter and healthier,' Shetty said."
"'We aren’t just trying to understand the biological mechanisms, we are translating and developing our findings into real-world therapies that could make a difference,' Shetty said."
ShinyLeftPad 4 minutes ago [-]
What that is is a tell of bad writing
damontal 4 minutes ago [-]
It’s a tell now. I see it I assume AI and disregard.
56 minutes ago [-]
asdf88990 1 hours ago [-]
Vibes. It is in the vibes.
anonym29 60 minutes ago [-]
Just a heads up, you're firmly in Poe's Law territory.
hyperhello 51 minutes ago [-]
Poe’s Law is the very essence of AI.
nullsanity 48 minutes ago [-]
[dead]
rylando 2 hours ago [-]
Kinda surprised A&M’s letting them use AI to write these things
scrubs 1 hours ago [-]
AI generated? Not demonstrated.
Whining by humans claiming AI? Predictable. Probable. Indeed LLM "complete the sentence" predictable.
dwa3592 2 hours ago [-]
c'mon you guys, chill. this is not a vaccine.
SubiculumCode 2 hours ago [-]
High impact journal for an interesting study that is admittedly largely out of my area of expertise. The limitation of it being done in animal models, is of course, noted, but also expected. The question I would ask is how well the underlying background research makes this outcome expected.
jskeicjwkxjwkd 1 hours ago [-]
Damn, that’s one hell of a way to say “is this any good though?”. Too many words for such a simple question.
Brian_K_White 17 minutes ago [-]
But "how well the underlying background research makes this outcome expected" does not mean "is this any good though".
It's also an actually interesting question.
It's one thing to find some things hard to follow, it's another to be proud of it.
SubiculumCode 1 hours ago [-]
Pretty much, lol. I started to say some other things but decided to say less.
earth-tattoo 2 hours ago [-]
That's exactly what I want: immortal mice!
ghurtado 2 hours ago [-]
That's a surprisingly underused plot for a sci Fi horror film.
Considering the grand total of experiments we've ran on the little guys, I'm kinda surprised we haven't bred Mousezilla yet
bookofjoe 40 minutes ago [-]
See also: “Flowers for Algernon”
bitwize 1 hours ago [-]
Or Pinky & the Brain
topgrain2 32 minutes ago [-]
The Secret of NIMH
dlcarrier 2 hours ago [-]
You joke, but rodents make great pets, because they are very social and have a range of personalities, but most only live a few years. I knew someone with a pet retired lab rat, and it lived much longer than the average fancy rat, but even then, it didn't even live half as long as the average cat or dog.
If we could breed or treat rodents to live longer, we could keep low-resource pets without as much loss.
block_dagger 2 hours ago [-]
Flowers for Algernon’s Brain
wingmanjd 47 minutes ago [-]
This short story was scarier to me as a kid than anything else I read at the time.
bookofjoe 37 minutes ago [-]
The movie adaptation — “Charlie” — is heartbreakingly good.
catlifeonmars 1 hours ago [-]
TFA reeks of over-sensationalizing. Here is a summary sans hyperbole:
Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus[1].
Abstract:
> Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age-related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide-binding domain, leucine-rich repeat family, and pyrin domain-containing 3 (NLRP3) inflammasomes, and the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway that triggers type 1 interferon (IFN-1) signalling. Studies have shown that extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) contain therapeutic miRNAs that can alleviate neuroinflammation. Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age. Compared with animals receiving vehicle treatment, the hippocampus of animals receiving hiPSC-NSC-EVs exhibited reductions in astrocyte hypertrophy, microglial clusters, and oxidative stress, along with elevated expression of antioxidant proteins and genes that maintain mitochondrial respiratory chain integrity. Moreover, hiPSC-NSC-EVs therapy decreased the levels of various proteins involved in the activation of the NLRP3 inflammasome, p38/mitogen-activated protein kinase, cGAS-STING-IFN-1, and Janus kinase and signal transducer and activator of transcription signalling pathways. Furthermore, in vitro assays using genetically engineered RAW cells and hiPSC-NSC-EVs, with or without targeted depletion of specific miRNAs, demonstrated that miRNA-30e-3p and miRNA-181a-5p, both present in hiPSC-NSC-EVs, can significantly inhibit the activation of the NLRP3 inflammasome and the STING pathway, respectively. Additionally, single-cell RNA sequencing conducted 7 days post-treatment revealed that hiPSC-NSC-EVs induce widespread transcriptomic changes in microglia, including increased expression of numerous genes that enhance oxidative phosphorylation and reduced expression of abundant genes that drive multiple proinflammatory signalling pathways. These changes mediated by hiPSC-NSC-EVs were also associated with improved cognitive and memory function. Thus, intranasal hiPSC-NSC-EVs therapy in late middle age can effectively diminish proinflammatory microglial transcriptome and signalling cascades that drive neuroinflammaging in the hippocampus, contributing to better brain function in old age.
I take N-acetylcysteine and it helps with brain fog also! Plus it reduces stress and irritability.
ai_fry_ur_brain 40 minutes ago [-]
And OCD symptoms, and many also benefit from better impulse control. Its more effective than SSRIs for some.
NAC is one of the only known treatments for trichotillomania, a under discussed but common condition that causes people to uncontrollably pull their hair out.
NAC has also been studied to reduce nicotine and alchohol cravings as well.
general_reveal 2 hours ago [-]
When can I snort this?
grg0 25 minutes ago [-]
I knew cocaine had to have an upside.
hoppp 2 hours ago [-]
Prepare a line for me also please
tryagainian 1 hours ago [-]
Grab me a bag while your there.
Joel_Mckay 45 minutes ago [-]
Many Brain-aging study sample pools are from young folks that died in accidents, aged homeless alcoholics, and individuals that were in declining health.
Most cultures find it taboo to donate their beloved family members bodies for scientific dissection. Thus, people get ingrained "[bigotry] with extra steps" similar to phrenology proponents.
"Old age and treachery will always beat youth and exuberance" =3
amingilani 2 hours ago [-]
...in mice.
> Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age.
That PR piece was brutal to navigate. Undoubtedly punched up by AI, it took far too long to even understand what the treatment entailed.
doginasuit 2 hours ago [-]
To be fair though, I think we owe the mice a positive research outcome.
antonvs 2 hours ago [-]
“Congratulations, you get improved brain function while we continue to run other experiments on you!”
ghurtado 2 hours ago [-]
You can now experience both physical pain and existential dread!
tryagainian 1 hours ago [-]
On the plus side, expect to see great works of literature authored by rodents.
earthnail 2 hours ago [-]
“There will be cake!”
SubiculumCode 2 hours ago [-]
The link to the actual paper was appreciated.
The context of whether findings will generalize outside of mouse models can depend a lot on specifics of the problem.
keepamovin 2 hours ago [-]
Ugh, I thought we were done with the Boomers....looks like they're gonna hang on.
fuckinpuppers 2 hours ago [-]
Mice get all the cool shit first
jjtheblunt 2 hours ago [-]
they get all the worst and most inane tortures too
secretslol 2 hours ago [-]
I even seen a mouse on youtube with it's own tiny EV sports car driving about!
The nasal spray reduced markers of inflammation in hippocampal microglial cells.
A lot of things reduce inflammation. That is not "reversing ageing".
Of course, "reduces inflammation" doesn't headline very well...
can you please share your methodology for detecting ai please?
That’s an AI tell. It may not be entirely LLM-generated, the various direct quotations help a lot, but there are touches that definitely feel like an LLM had a hand here.
"Over decades, it doesn’t just wear down, it also starts to run hot." "... the therapy didn’t just clear brain fog, it physically improved the brain’s ability to process and store information."
The quotes as well: "'... Not just living longer, but living smarter and healthier,' Shetty said." "'We aren’t just trying to understand the biological mechanisms, we are translating and developing our findings into real-world therapies that could make a difference,' Shetty said."
Whining by humans claiming AI? Predictable. Probable. Indeed LLM "complete the sentence" predictable.
It's also an actually interesting question.
It's one thing to find some things hard to follow, it's another to be proud of it.
Considering the grand total of experiments we've ran on the little guys, I'm kinda surprised we haven't bred Mousezilla yet
If we could breed or treat rodents to live longer, we could keep low-resource pets without as much loss.
Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signalling, in Aged Hippocampus[1].
Abstract:
> Neuroinflammaging, a moderate, chronic, and sterile inflammation in the hippocampus, contributes to age-related cognitive decline. Neuroinflammaging comprises the activation of the nucleotide-binding domain, leucine-rich repeat family, and pyrin domain-containing 3 (NLRP3) inflammasomes, and the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway that triggers type 1 interferon (IFN-1) signalling. Studies have shown that extracellular vesicles from human induced pluripotent stem cell-derived neural stem cells (hiPSC-NSC-EVs) contain therapeutic miRNAs that can alleviate neuroinflammation. Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age. Compared with animals receiving vehicle treatment, the hippocampus of animals receiving hiPSC-NSC-EVs exhibited reductions in astrocyte hypertrophy, microglial clusters, and oxidative stress, along with elevated expression of antioxidant proteins and genes that maintain mitochondrial respiratory chain integrity. Moreover, hiPSC-NSC-EVs therapy decreased the levels of various proteins involved in the activation of the NLRP3 inflammasome, p38/mitogen-activated protein kinase, cGAS-STING-IFN-1, and Janus kinase and signal transducer and activator of transcription signalling pathways. Furthermore, in vitro assays using genetically engineered RAW cells and hiPSC-NSC-EVs, with or without targeted depletion of specific miRNAs, demonstrated that miRNA-30e-3p and miRNA-181a-5p, both present in hiPSC-NSC-EVs, can significantly inhibit the activation of the NLRP3 inflammasome and the STING pathway, respectively. Additionally, single-cell RNA sequencing conducted 7 days post-treatment revealed that hiPSC-NSC-EVs induce widespread transcriptomic changes in microglia, including increased expression of numerous genes that enhance oxidative phosphorylation and reduced expression of abundant genes that drive multiple proinflammatory signalling pathways. These changes mediated by hiPSC-NSC-EVs were also associated with improved cognitive and memory function. Thus, intranasal hiPSC-NSC-EVs therapy in late middle age can effectively diminish proinflammatory microglial transcriptome and signalling cascades that drive neuroinflammaging in the hippocampus, contributing to better brain function in old age.
[1]: https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
NAC is one of the only known treatments for trichotillomania, a under discussed but common condition that causes people to uncontrollably pull their hair out.
NAC has also been studied to reduce nicotine and alchohol cravings as well.
Most cultures find it taboo to donate their beloved family members bodies for scientific dissection. Thus, people get ingrained "[bigotry] with extra steps" similar to phrenology proponents.
https://en.wikipedia.org/wiki/Simpson%27s_paradox
"Old age and treachery will always beat youth and exuberance" =3
> Therefore, this study examined the effects of late middle-aged (18-month-old) male and female C57BL6/J mice receiving two intranasal doses of hiPSC-NSC-EVs on neuroinflammaging in the hippocampus at 20.5 months of age.
— https://isevjournals.onlinelibrary.wiley.com/doi/10.1002/jev...
M. Night Shyamalan wrote a screenplay about the latter book, and it was made into a popular movie.
https://youtube.com/shorts/E74r-ybeQfE
Someone needs to put an octopus in a mini vehicle.